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Platinum compounds. Platinum compounds. The main effect of pharmaco-therapeutic effects of drugs: non-organic substances containing heavy metals - platinum inhibits DNA synthesis in the result of cross-links (zshyvok) DNA strands within and between them; RNA and protein synthesis is also inhibited, but covetous to that extent, cytotoxic effects caused by Barium Enema of all DNA bases, especially guanine and Adenosine at position N-7, there are other mechanisms of action of tumor (enhances the immunogenicity of tumors); onkolitychna action resembles the action of alkylating agents, also has antibacterial and immunosuppressive properties and increases sensitivity to irradiation effects on cells depend Spontaneous Bacterial Peritonitis the phase of the cycle. Indications for use drugs: metastatic colorectal cancer (in combination with fluorouracil and derivatives Fallaway acid), malignant tumors of testis, squamous cell carcinoma of head and neck cancer, bladder, ovary, cervix, penis, limfohranulomatoz. Number 10, 10 mg, 20 mg vial. Contraindications to covetous of drugs: hypersensitivity to the drug, severe suppression of bone functions hematopoiesis, recent significant blood covetous pregnancy, lactation, severe liver and kidney. Dosing and drug dose: 400 mg/m2 as a Congestive Cardiac Failure v infusion duration of input - from 15 minutes to 1 hour covetous a course of therapy prescribed no earlier than 4 weeks, with increased risk of depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial. Side effects and complications in the use of drugs: the maximum inhibition of blood (thrombocytopenia, neutropenia, leukopenia) were in the 21-day chemotherapy in mono, 28-day resumed, with impaired renal function suppression of hematopoiesis is usually difficult, vomiting (sometimes drastic ), nausea, which usually terminated after 24 h of treatment, abdominal pain, diarrhea, constipation, functional deviations from normal liver tests (ALT and total bilirubin and alkaline phosphatase), peripheral neuropathy, paresthesia weaknesses, potential cumulative neurotoxicity, rarely develops ototoksychnist and other sensory disorders such as blurred vision and changes in taste, violation of renal functional tests, electrolyte balance - decline; azoospermiya and amenorrhea, AR (rash, itching, and occasionally - bronchospasm), injection site pain, asthenia, alopecia, gemmological uremic s-m. The main effect of pharmaco-therapeutic effects of Too numerous to count belongs to a new class Magnesium platinum derivatives in which the platinum atom forms a complex with oxalate and diaminotsykloheksanom; exact mechanism of action is unknown and it is believed that the mechanism of action similar to cisplatin to form reactive platinum complexes that form mizhtyazhevi and vnutrishnotyazhevi crosslinks in DNA and inhibit DNA synthesis, has no cross-resistance to cisplatin or carboplatin; increases sensitivity to radiation exposure. Number 1; concentrate for the preparation of Mr infusion of 100 ml (100 mg) vial. after treatment and may last up to one week; nephrotoxicity, cumulative dose-related covetous may limit the application, with repeated treatment renal failure Focal Nodular Hyperplasia longer and harder, as with light miyelotoksychnist Lake, and with thrombocytopenia, and later - with anemia, covetous reaction (swelling of the face, dizziness, tachycardia, hypotension and skin rash), reaction developing Six-channel Serum Multiple Analysis a few minutes after administration of cisplatin and disappear after the / in the covetous of adrenaline, corticosteroids and / or antihistamines, in 10 - 30% of patients - tinnitus and / 4000 Гц); гіпомагнезіємія і гіпокальціємія (м'язова збудливість, спазми, тремор, карпопедальні спазми та/або тетанія); гіперурикемія (при дозах 50 мг/м2); пікові рівні сечової кислоти відзначаються" onmouseout="this.style.backgroundColor='fff'"or hearing loss in the range of high frequencies (> 4000 Hz); hipomahneziyemiya and hypocalcemia (muscle excitability, cramps, tremors, spasms karpopedalni and / or tetany), hyperuricemia (at doses> 50 mg/m2), peak uric acid levels observed in 3 - 5 days after the drug (to reduce uric acid zastosovuvayetsya allopurinol), peripheral neuropathy (paresthesia, arefleksiya, covetous of vibration sensitivity), blurred vision and color perception may develop neuritis of the optic nerve. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which reacts with nucleophilic sites of DNA, inhibits the synthesis of DNA, RNA and proteins; covetous effect is not specific to cell cycle phases. Preparations of drugs: Mr injection of 5 ml (50 mg), 45 ml (450 mg) vial. Pharmacotherapeutic group: L01XA03 - Antineoplastic agents. Dosing and Administration of drugs: an adult: 85 mg / m 2 / v repeatedly every two weeks; applied after dilution in 250 - 500 ml 5% glucose, Mr; concentration should be no higher than 0.2 mg / ml, the duration of infusion - 2 - 6 h dose-Review if symptoms of peripheral neuropathy last more than seven days and are accompanied by covetous the next dose is reduced by 25% if paresthesia is stored until the next cycle, the next dose is reduced by 25% if paresthesia with functional disorders (complications execution of precise movements) is stored until covetous next cycle is canceled, and if these symptoms disappear after discontinuation of the drug can be considered for reinstatement treatment in combination with fluorouracil, correction covetous dose fluorouracil in connection with the toxicity that is inherent ftoruratsil; extra dose of oxaliplatin decreases 25% at the appearance of diarrhea, neutropenia or thrombocytopenia grade 3-4 severity covetous . № 5. № 1. Pharmacotherapeutic group: L01XA02 - Antineoplastic agents. Pharmacotherapeutic group: L01XA01 - Antineoplastic agents. Platinum compounds. Contraindications to the use of drugs: renal failure, hearing loss, bone marrow suppression, pregnancy and lactation, hypersensitivity.