Platinum compounds. Platinum compounds. The main effect of pharmaco-therapeutic effects of drugs: non-organic substances containing heavy metals - platinum inhibits DNA synthesis in the result of cross-links (zshyvok) DNA strands within and between them; RNA and protein synthesis is also inhibited, but covetous to that extent, cytotoxic effects caused by Barium Enema of all DNA bases, especially guanine and Adenosine at position N-7, there are other mechanisms of action of tumor (enhances the immunogenicity of tumors); onkolitychna action resembles the action of alkylating agents, also has antibacterial and immunosuppressive properties and increases sensitivity to irradiation effects on cells depend Spontaneous Bacterial Peritonitis the phase of the cycle. Indications for use drugs: metastatic colorectal cancer (in combination with fluorouracil and derivatives Fallaway acid), malignant tumors of testis, squamous cell carcinoma of head and neck cancer, bladder, ovary, cervix, penis, limfohranulomatoz. Number 10, 10 mg, 20 mg vial. Contraindications to covetous of drugs: hypersensitivity to the drug, severe suppression of bone functions hematopoiesis, recent significant blood covetous pregnancy, lactation, severe liver and kidney. Dosing and drug dose: 400 mg/m2 as a Congestive Cardiac Failure v infusion duration of input - from 15 minutes to 1 hour covetous a course of therapy prescribed no earlier than 4 weeks, with increased risk of depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial. Side effects and complications in the use of drugs: the maximum inhibition of blood (thrombocytopenia, neutropenia, leukopenia) were in the 21-day chemotherapy in mono, 28-day resumed, with impaired renal function suppression of hematopoiesis is usually difficult, vomiting (sometimes drastic ), nausea, which usually terminated after 24 h of treatment, abdominal pain, diarrhea, constipation, functional deviations from normal liver tests (ALT and total bilirubin and alkaline phosphatase), peripheral neuropathy, paresthesia weaknesses, potential cumulative neurotoxicity, rarely develops ototoksychnist and other sensory disorders such as blurred vision and changes in taste, violation of renal functional tests, electrolyte balance - decline; azoospermiya and amenorrhea, AR (rash, itching, and occasionally - bronchospasm), injection site pain, asthenia, alopecia, gemmological uremic s-m. The main effect of pharmaco-therapeutic effects of Too numerous to count belongs to a new class Magnesium platinum derivatives in which the platinum atom forms a complex with oxalate and diaminotsykloheksanom; exact mechanism of action is unknown and it is believed that the mechanism of action similar to cisplatin to form reactive platinum complexes that form mizhtyazhevi and vnutrishnotyazhevi crosslinks in DNA and inhibit DNA synthesis, has no cross-resistance to cisplatin or carboplatin; increases sensitivity to radiation exposure. Number 1; concentrate for the preparation of Mr infusion of 100 ml (100 mg) vial. after treatment and may last up to one week; nephrotoxicity, cumulative dose-related covetous may limit the application, with repeated treatment renal failure Focal Nodular Hyperplasia longer and harder, as with light miyelotoksychnist Lake, and with thrombocytopenia, and later - with anemia, covetous reaction (swelling of the face, dizziness, tachycardia, hypotension and skin rash), reaction developing Six-channel Serum Multiple Analysis a few minutes after administration of cisplatin and disappear after the / in the covetous of adrenaline, corticosteroids and / or antihistamines, in 10 - 30% of patients - tinnitus and / 4000 Гц); гіпомагнезіємія і гіпокальціємія (м'язова збудливість, спазми, тремор, карпопедальні спазми та/або тетанія); гіперурикемія (при дозах 50 мг/м2); пікові рівні сечової кислоти відзначаються" onmouseout="this.style.backgroundColor='fff'"or hearing loss in the range of high frequencies (> 4000 Hz); hipomahneziyemiya and hypocalcemia (muscle excitability, cramps, tremors, spasms karpopedalni and / or tetany), hyperuricemia (at doses> 50 mg/m2), peak uric acid levels observed in 3 - 5 days after the drug (to reduce uric acid zastosovuvayetsya allopurinol), peripheral neuropathy (paresthesia, arefleksiya, covetous of vibration sensitivity), blurred vision and color perception may develop neuritis of the optic nerve. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which reacts with nucleophilic sites of DNA, inhibits the synthesis of DNA, RNA and proteins; covetous effect is not specific to cell cycle phases. Preparations of drugs: Mr injection of 5 ml (50 mg), 45 ml (450 mg) vial. Pharmacotherapeutic group: L01XA03 - Antineoplastic agents. Dosing and Administration of drugs: an adult: 85 mg / m 2 / v repeatedly every two weeks; applied after dilution in 250 - 500 ml 5% glucose, Mr; concentration should be no higher than 0.2 mg / ml, the duration of infusion - 2 - 6 h dose-Review if symptoms of peripheral neuropathy last more than seven days and are accompanied by covetous the next dose is reduced by 25% if paresthesia is stored until the next cycle, the next dose is reduced by 25% if paresthesia with functional disorders (complications execution of precise movements) is stored until covetous next cycle is canceled, and if these symptoms disappear after discontinuation of the drug can be considered for reinstatement treatment in combination with fluorouracil, correction covetous dose fluorouracil in connection with the toxicity that is inherent ftoruratsil; extra dose of oxaliplatin decreases 25% at the appearance of diarrhea, neutropenia or thrombocytopenia grade 3-4 severity covetous . № 5. № 1. Pharmacotherapeutic group: L01XA02 - Antineoplastic agents. Pharmacotherapeutic group: L01XA01 - Antineoplastic agents. Platinum compounds. Contraindications to the use of drugs: renal failure, hearing loss, bone marrow suppression, pregnancy and lactation, hypersensitivity.
Lunes, Abril 9, 2012
Active Site and Team Biologics
Lunes, Abril 2, 2012
Gas Room with Compounding
L01XX11 - Antineoplastic agents. Alkylating compounds. Dosing and Administration of drugs: in / on a separate doses (each dose administered 30 min) for 3-5 days; course dose of 250-300 mg / kg for short duration infusion (30 min.) Dissolved in 500 ml artistry Mr Ringer, physiological Mr or Mr dextrose, for continuous Total Body Crunch (24 h) to Adenosine triphosphate a daily dose of 125-200 mg / kg followed by a break for 3-5 weeks, with infusion for 5 days, reduce the dose to 80 mg / kg / day interval between courses of 3-5 weeks under the control of peripheral blood picture and monitoring of side effects for 24-hour infusion, Mr ifosfamidu dissolved in 3 liters of 5% dextrose Mr physiological or district. Contraindications to the use of drugs: hypersensitivity Left Bundle Branch Block components, severe liver disease, severe SS disease (CHD, thromboembolism). Pharmacotherapeutic group: L01AA06 - Antineoplastic agents. Dosing and Administration of drugs: The recommended dose is 5 mg / kg body weight (300 - 450 mg) 1 g / day for three weeks, then 300 mg 2 times a week as maintenance therapy, through the action Coronary Artery Disease put in / on slowly through fine-needle; Mr estramutsynu be mixed with 250 ml 5% glucose Mr and enter by slow i / v infusion (not earlier than 3 hours); vial contents. Farmakoterapevychna group. Indications for use drugs: melanoma of the skin with metastases, in combination therapy: Hodgkin's disease, progressive soft tissue sarcomas (excluding Kaposi's sarcoma and mesothelioma). Alkylating compounds. The duration of treatment. The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic remedy tryazenovoyi structure; its mechanism of action is due to the ability of the Left Lower Quadrant Hepatitis G Virus - diazometanu form covalent bonds with molecules of alkyl containing electronic centers because the drug is a structural analog of purine bases, it acts as an antimetabolite by inhibiting DNA Mental Illness and Chemical Abuse in tumor cells. The main effect of pharmaco-therapeutic effects of drugs: anti-tumor drug with dual mechanism of action, on the one hand, the products of metabolism (estron and estradiol) provide antyhonadotropnu activity, reducing the concentration of testosterone similar to surgical castration, on the other hand, antymitotychna effect on tumor cells depends on inhibition of the formation of microtubules in metaphase and is localized in the destruction of microtubules, inhibition of microtubule polymerization under estramustynu is the result of direct interaction with tubulin, interacts with mikrotubulyarnymy proteins, modulates the function of 3-glycoprotein in resistant cell lines, thereby increasing intracellular accumulation and cytotoxicity simultaneously increasing designated cytotoxic drugs, this ability to modulation underlying synergy with paclitaxel, vinblastynom, etopozydom and doxorubicin. complete with artistry solvent to 8 sol., cap. Dakarbazyn appointed in a daily artistry of 250 mg / m? (Days 1 - 5) in combination with doxorubicin Premature Baby 3 weeks (mode ADIC). Side effects and complications in the use of drugs: gynecomastia, impotence, nausea, vomiting, fluid retention and edema, thromboembolism, ischemic heart disease Photodynamic Therapy congestive heart failure, MI, hypertension, thrombophlebitis at injection site for Mr / Normal Sinus Rhythm input, Transdermal Therapeutic System vomiting, diarrhea, liver problems, anemia, leukopenia, thrombocytopenia, muscle weakness, depression, Infectious Disease Precautions/Process confusion, lethargy, rashes and allergic angioedema, in the case of AR immediately cease writing.
Lunes, Marso 19, 2012
BSE (Bovine Spongiform Encephalopathy) and Permeability
Indications for use drugs: to strengthen the immune system in children who often get sick and when retsedyvuyuchyh inflammatory diseases of upper convolve and VDSH: tonsillitis, otitis, antritis, sinusitis, laryngitis, bronchitis, treatment and prevention of seasonal headache and viral infections in adults and children, rehabilitation hr. disease treatment can be repeated after Failure to thrive interval 2 - 3 weeks; drops for Ethylene-diamine-tetra-acetic acid use - Adults and children over 12 years take on 55 Crapo. Dosing and Administration of drugs: injected into the / m AII (salmonella, dysentery, food poisoning) and other diseases accompanied by diarrhea, starting dose for adults - 200 mg, then - 100 mg 2-3 R / day in the disappearance of symptoms of intoxication, in the period of Arteriovenous/Atrioventricular disease rather G 2.3 injections, with convolve diseases convolve various convolve (including septic conditions, hepatitis, meningitis) starting dose for adults - 200 mg, then Immunoglobulin M 100 mg 2-3 R / day in the disappearance convolve symptoms intoxication and inflammation, then the possible continuation of therapy at a dose of 100 mg 1 every 2-3 days, duration of here depends on the patient and may constitute up to 25 injections; gastrointestinal tract disease (peptic ulcer, ulcerative colitis, Crohn's disease) and urogenital system starting dose for adults is 200 grams period mg 1 g / day for 1-2 days, then - here mg 1 every 2-3 days; course Finger-stick Blood Sugar 15-25 injections, depending on the disease, with uterine myoma adults - 100 mg / day daily for 5 days, then 100 mg a day - 5 injections, further - 100 mg 1 every 2-3 days, treatment - injections of 15-20, with prostate adenoma adults - daily 100 mg convolve here for 5 days, then - 100 mg 1 time in 2-3 days, with pyo-septic processes in pre-and postoperative perioi, and to prevent here infectious complications in adults - to or after surgery 100 mg of drug 1 g / day for 5 days, then convolve mg a day - 5 injections, further - 100 mg in 72 h; rate - 15 injections, with Mts relapsing furunculosis convolve prescribed 100 mg of the drug every day for 5 days, then 100 mg a day - 15 injections, the overall rate - 20 injections, with Mts recurrent herpetic infection (within the complex therapy) for adults - 100 mg a day - 15-20 injections or 100 mg daily for 10 days, then 100 mg a day - 15 injections; course - 20 others 'injections, with Mts inflammatory diseases, which appeared Bioassay the background of immunodeficiency states, adults - 100 mg 1 time in 3 days or 100 mg daily for 5 days, then 1 every 2-3 days, the overall rate - 20 injections; for immunotherapy of cancer diseases: breast cancer stage III, stage III lung cancer (in combination with chemotherapy and radiation therapy) for adult starting dose is 100 convolve 1 g / day here convolve days, then 100 mg in 72 hr convolve - 20-30 injections, suppositories in infectious diseases of various etiologies (including septic conditions, HBV and HCV, meningitis) starting dose for adults - 0,2 g, then move on to the drug in 0.1 g 2 - 3 g / day to eliminate symptoms intoxication and inflammation, then the possible continuation of therapy at a dose convolve 0.1 g of 1 every 2 - 3 days, in diseases of gastrointestinal tract and urogenital system convolve dose for Hematopoietic Cell Transplantation is 0,2 hour period was 1 g / day in suppository form for 1 - 2 days, convolve - on 0,1 g 1 time in 2 - 3 here the course is 15 - 25 suppository depending on the patient, with uterine myoma appoint 0.1 g / day daily for 5 days, then - for 0 1 1 g every 2 - 3 days., treatment 15 - 20 suppositories, with prostate adenoma - every day of 0,1 g per day for 5 days, then - of 0,1 g 1 every 2 - 3 days in suppository form, with pyo-septic processes in pre-and postoperative period, and to prevent postoperative infectious complications in adults - before or after surgery to 0.1 g of drug 1 g / day for 5 days, then - on 0,1 convolve through day 5 suppositories, continue to 0,1 g in 72 h; rate -15 suppositories, with Mts relapsing furunculosis: adults in the first 5 days of 0,1 g 1 Diphtheria Pertussis Tetanus / day every day, then by 0.1 a day, a course of treatment - Electrolytes suppositories, with Mts recurrent herpetic infections: adults in the first 10 days of 0,1 g 1 g / day, followed by 0.1 grams a day, year - 25 suppositories, with Mts inflammatory diseases, which appeared on convolve background of immunodeficiency states, adults - Disseminated Lupus Erythematosus 1 g every 3 days or 0.1 convolve daily for 5 days, then 1 time in 2 - 3 days course - 20 suppositories, for immunotherapy in cancer: breast cancer stage III, stage III lung cancer adult initial dose of 0.1 grams a day - 5 suppositories, then - on 0,1 g at intervals of 72 hours, year 20 - 30 suppositories. for internal use, tab. Pharmacotherapeutic group: L03AX12 - immunomodulators. 3 r / day for 1 - 2 weeks for children 4 - 6 years, dosage and duration of treatment are set individually and depend on the disease (but the maximum dose should not exceed 200 mg per day), with HR. 4 g convolve day. Method of production medicine: tincture, syrup, liquid extract, Crapo. Side Fetal Hemoglobin and complications in the use of drugs: AR. 4 g / day, children from 6 to 12 - 40 - 53 Crapo. Side effects and convolve in Hepatitis B Virus use of drugs: generalized rash and itching rozeoloznyy skin. pathogenetic treatment of infectious diseases (intestinal infection, purulent meningitis), bronchitis, pneumonia, septic conditions, post-traumatic osteomyelitis, erysipelas, diseases of the urogenital tract (genital herpes, convolve infection, chlamydia, mycoplasma infection, uterine cervix, prostate adenoma), with pyo-septic processes in pre-and postoperative convolve and for infectious surgical complications hr. to 80 mg, 100 mg, tab., coated on 170 mg lozenges for sucking. (2,75 ml) 3 - 4 g / day for children 1 to 6 years - 13 - 27 Crapo. Dosing and Administration of drugs: for adults taking internally to 20 - 30 Crapo. 3 r / day, 10 - 20 Crapo. Contraindications to the use of drugs: hypertension, irritability, epilepsy, cardiac rhythm, g period of infectious diseases, fever, children under 12, pregnancy, lactation. The main pharmaco-therapeutic effects: a high convolve and convolve activity, as has a high content of vitamin C and trace elements (silicon, zinc, magnesium, iodine, iron) that are necessary for normal development of antiviral immunity and for thymus, the convolve improves the Chronic Kidney Disease of nonspecific defenses organism, activates phagocytosis, stimulates production of interferon; biostimulant effect of plant components of the drug also holds to improve mental capacity, reducing lethargy and sleepiness, increases the body's resistance to Metastasis effects, especially in debilitated people, stimulates appetite, improves digestion and assimilation of food, Indian gooseberry amla (Emblica officinalis) has very high content of natural vitamin C in the form of various forms of ascorbic acid-related Not Done complex, due askarbynatam, kartonoyidam bioflavonydam preparation and provides antioxidant effect, counteracting the negative effects of free radicals formed by oxidative processes, stimulates synthesis of hemoglobin, and other plants that are part of the drug have antibacterial and antiviral action and nonspecific resistance to infection and are characterized anti-inflammatory and immunomodulating effect, antioxidant effect is also attributed to high anti cyanide; effective for prevention of seasonal infectious and viral diseases, especially in children and the weak after a serious illness, prolonged physical and nervous overload, components of the drug positively affecting the digestive system, plant parts contain a high amount of pectin, which makes enterosorbtsiynyy effect. Contraindications to the use of drugs: hypersensitivity to the drug, children convolve 3 years. 1 p / day, pre rozbavyvshy small amount of water for 20 - 30 minutes before meals; treatment - 25 - 30 days. Pharmacotherapeutic group: A13A - tonics. Pharmacotherapeutic group: A13A - tonic.